Wrinkles on earlobes slowly develop as we age and our earlobes deflate, just like the rest of your face! In the medical literature an earlobe crease has been correlated with some cardiovascular diseases. The simplest way to treat earlobe wrinkles is to place a small amount of filler in the earlobe. The wrinkles immediately improve. Filler in the earlobes tend to last significantly longer than in most other parts of the face. If it helps make you feel better, probably no one else is noticing your wrinkled earlobes!